DMS

Dermatomyositis

 

DMS – Dermatomyositis is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences

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DMS has a significant association with three loci:

PAN2 (A);

MAP3K7CL (B) and

DLA-DRB1 (C).


Gene PAN2 (A) – mutation g.627760G>A, encoding p.Arg492Cys;

gene MAP3K7CL (B) – indel (c.383_392ACTCCACAAA>GACT;

DLA-DRB1 – allele DLA-DRB1*002:01 (C), any other allele DLA-DRB1 (c)

A, B, C alleles - risk of development of the dermatomyositis;

a, b, c – wild type alleles